Integrated and Composite Outcome Measures in Alzheimer's Disease Clinical Trials: A Subtle but Important Difference?
![Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages](https://www.frontiersin.org/files/Articles/1021792/fnagi-14-1021792-HTML/image_m/fnagi-14-1021792-g004.jpg)
Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages
![Table 3 from Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. | Semantic Scholar Table 3 from Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/49e751e0f10eca128d4e6295d008d7daa164b71f/4-Table3-1.png)
Table 3 from Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. | Semantic Scholar
Baseline and follow-up cognitive function by CDR, MMSE, and CDR-SB in... | Download Scientific Diagram
![Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages](https://www.frontiersin.org/files/Articles/1021792/fnagi-14-1021792-HTML/image_m/fnagi-14-1021792-g002.jpg)
Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages
![Table 1 from Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. | Semantic Scholar Table 1 from Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/49e751e0f10eca128d4e6295d008d7daa164b71f/3-Table1-1.png)
Table 1 from Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. | Semantic Scholar
![Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages](https://www.frontiersin.org/files/Articles/1021792/fnagi-14-1021792-HTML/image_m/fnagi-14-1021792-t001.jpg)
Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages
![A Mean Clinical Dementia Rating Sum of Boxes (CDR-SB) Scores for All... | Download Scientific Diagram A Mean Clinical Dementia Rating Sum of Boxes (CDR-SB) Scores for All... | Download Scientific Diagram](https://www.researchgate.net/publication/330301005/figure/fig12/AS:713685894975488@1547167385337/A-Mean-Clinical-Dementia-Rating-Sum-of-Boxes-CDR-SB-Scores-for-All-Subjects-On.png)
A Mean Clinical Dementia Rating Sum of Boxes (CDR-SB) Scores for All... | Download Scientific Diagram
![Table 4 from Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. | Semantic Scholar Table 4 from Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/8b6b693ec2dae32a9d271258d5e4deea2b08f87a/3-Table4-1.png)
Table 4 from Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. | Semantic Scholar
![Table 5 from Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. | Semantic Scholar Table 5 from Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/8b6b693ec2dae32a9d271258d5e4deea2b08f87a/4-Table5-1.png)
Table 5 from Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. | Semantic Scholar
![PSYCHOMETRIC PROPERTIES OF THE CLINICAL DEMENTIA RATING – SUM OF BOXES AND OTHER COGNITIVE AND FUNCTIONAL OUTCOMES IN A PRODROMAL ALZHEIMER'S DISEASE POPULATION • The Journal of Prevention of Alzheimer's Disease PSYCHOMETRIC PROPERTIES OF THE CLINICAL DEMENTIA RATING – SUM OF BOXES AND OTHER COGNITIVE AND FUNCTIONAL OUTCOMES IN A PRODROMAL ALZHEIMER'S DISEASE POPULATION • The Journal of Prevention of Alzheimer's Disease](https://www.jpreventionalzheimer.com/wp-content/uploads/2020/12/TAB-1-MCDOUGALL-copie.gif)
PSYCHOMETRIC PROPERTIES OF THE CLINICAL DEMENTIA RATING – SUM OF BOXES AND OTHER COGNITIVE AND FUNCTIONAL OUTCOMES IN A PRODROMAL ALZHEIMER'S DISEASE POPULATION • The Journal of Prevention of Alzheimer's Disease
![Clinical dementia rating scale–sum of boxes and hippocampal volume vs.... | Download Scientific Diagram Clinical dementia rating scale–sum of boxes and hippocampal volume vs.... | Download Scientific Diagram](https://www.researchgate.net/publication/257309478/figure/fig2/AS:272564970848276@1441995961762/Clinical-dementia-rating-scale-sum-of-boxes-and-hippocampal-volume-vs-status-at-study.png)
Clinical dementia rating scale–sum of boxes and hippocampal volume vs.... | Download Scientific Diagram
ABC Dementia Scale: A Quick Assessment Tool for Determining Alzheimer's Disease Severity. - Document - Gale OneFile: Health and Medicine
![Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages](https://www.frontiersin.org/files/Articles/1021792/fnagi-14-1021792-HTML/image_m/fnagi-14-1021792-g003.jpg)
Frontiers | Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages
![Disease progression modeling of CDR-SB in Alzheimer's disease. (A) The... | Download Scientific Diagram Disease progression modeling of CDR-SB in Alzheimer's disease. (A) The... | Download Scientific Diagram](https://www.researchgate.net/publication/346025857/figure/fig3/AS:959984053518345@1605889442470/Disease-progression-modeling-of-CDR-SB-in-Alzheimers-disease-A-The-pattern-of-CDR-SB.png)
Disease progression modeling of CDR-SB in Alzheimer's disease. (A) The... | Download Scientific Diagram
![Clinical Dementia Rating–Sum of Boxes: A Promising Outcome Measure for Improved Sensitivity to Treatment Efficacy in Future AD Clinical Trials | Cogstate Clinical Dementia Rating–Sum of Boxes: A Promising Outcome Measure for Improved Sensitivity to Treatment Efficacy in Future AD Clinical Trials | Cogstate](https://www.cogstate.com/wp-content/uploads/2021/03/Social-Media-Posts6.png)
Clinical Dementia Rating–Sum of Boxes: A Promising Outcome Measure for Improved Sensitivity to Treatment Efficacy in Future AD Clinical Trials | Cogstate
![Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative: Neuropsychiatric Disease and Treatment: Vol 10, No null Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative: Neuropsychiatric Disease and Treatment: Vol 10, No null](https://www.tandfonline.com/cms/asset/49062bbe-cd44-4bfa-8826-84369ecde5f7/dndt_a_62323_sf0003_c.jpg)
Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative: Neuropsychiatric Disease and Treatment: Vol 10, No null
![Aducanumab Treatment in Clinical Trials Lowered Participants' Levels of Potential Blood Biomarker for Alzheimer Disease - Practical Neurology Aducanumab Treatment in Clinical Trials Lowered Participants' Levels of Potential Blood Biomarker for Alzheimer Disease - Practical Neurology](https://core4.bmctoday.net/storage/images/211112_AducanumabTable2_1636729535.jpg)